LCMS Senior Scientist

About Pfizer
A career at Pfizer offers opportunity, ownership and impact. All over the world, Pfizer colleagues work together to positively impact health for everyone, everywhere. Our colleagues have the opportunity to grow and develop a career that offers both individual and company success; be part of an ownership culture that values diversity and where all colleagues are energized and engaged; and the ability to impact the health and lives of millions of people. Pfizer, a global leader in the biopharmaceutical industry, is continuously seeking top talent who are inspired by our purpose to innovate to bring therapies to patients that significantly improve their lives.
Role Description
An opportunity is available for a highly motivated expert in quantitative protein mass spectrometry to join the LC-MS/MS group in Biomedicine Design Andover. The role will provide expertise and laboratory support in the quantitative analysis of protein biomarkers and protein target biomeasures in support of translational and exploratory clinical projects. The successful applicant will be primarily responsible for the development and implementation of innovative bioanalytical methods using protein immunoaffinity enrichment techniques in conjunction with LC-MS-based detection. This includes the assessment of concentrations in blood and tissues, engagement with the therapeutic and turnover as input to mechanistic models supporting target evaluation, clinical dose or efficacy projections. Close collaboration with translational modeling and simulation (TMS) scientists will enable the successful candidate to optimize laboratory deliverables. The senior scientist will join a state-of-the-art laboratory with deep expertise in protein quantification by mass spectrometry and is expected to build strong collaborative partnerships, both within and outside the group. This position requires strong bioanalytical expertise, solid background in protein biochemistry, proven expertise in immunoanalytical procedures and triple quadrupole as well as high resolution quantitative mass spectrometry.
Responsibilities
Responsible for the discovery, development, validation, and implementation of target, pharmacodynamic biomeasure/biomarker assays in support of translational and exploratory clinical projects using mass spectrometry. As a strong collaborator and based on demonstrated project impact, develop deep partnerships in a matrix environment, influencing project strategies. Participate and lead in technology development and implementation by exploring novel concepts and innovative workflows to expand the group's biomarker bioanalytical capabilities. Participate in all phases of mass spectrometry laboratory operations including technology evaluations, the development of sample preparation and separation methods, data analysis, interpretation, reporting and follow up discussions with the project teams on utilizing the data in appropriate decision making. Ensure all tasks and responsibilities are carried out according to scientific and ethical standards e.g. responsible for eWorkbook record keeping. Publications in peer-reviewed scientific journals and external / internal presentations are expected.
Qualifications
Qualified applicants hold a Ph.D. plus 1-3 years of post-doctoral experience required or related degree with equivalent years of experience, ideally mostly in industry. Expertise in development, characterization, and implementation of biomarker assays based on quantitative protein mass spectrometry for drug development. Experience and knowledge in operation of modern triple quadrupole and ion trap/orbitrap mass spectrometers and associated control and data analysis software systems. Knowledge and application of complex sample preparation methodologies as applied to quantitative protein mass spectrometry workflows techniques including immuno-analytical techniques and tissue preparation/tissue bioanalysis. Good understanding of protein biochemistry. PHYSICAL/MENTAL REQUIREMENTS As appropriate for lab based role. NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS Lab based position requiring to perform all typical laboratory related activities Based in Andover Occasional travel to Cambridge (Kendal Square) is required, depending on project needs
EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.


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